Aside from the obvious levity in the title, and the preposterous notion that any individual has the answers to all truth, the biggest problem with knowing it all is that then the conclusions must be accepted, and evidence must not contradict the conclusions. After all, if we accept evidence contrary to that which we know, then we cannot have known it all. That creates a shorted circuit in the brains of some people. Seriously. They cannot get past the point of looping confirmation bias once a preconceived notion, long held and somewhat sacred, is challenged for truth.
I suspect there will be people who think I am talking about them in particular, and there will be others who think I am talking about other people and not them. However, I am talking about everyone in general and no one in particular. We all are susceptible to thinking we have the answers even though we don't fully understand the questions. Besides, even if we don't have the answers, we can have opinions that we don't fully understand.
And the loop begins anew.